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Anti-Calponin-1 Rabbit Monoclonal Antibody

Monoclonal antibody to detect Calponin-1 in human samples.
Catalog #: A1609

In stock

$295.00

Product Details

Cat # +Size A1609-50
Size 50 µl
Antibody Target Calponin-1
Alternate Name Calponin 1 basic smooth muscle; Calponin H1 smooth muscle; Calponin-1; CNN1; Cnn1; Sm Calp; SMCC
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the C-terminus of human Calponin-1
Accession # P51911
Gene ID 1264
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Affinity purified
Species Reactivity Human
Application WB, IHC
Positive Control WB: mouse heart tissue lysates, ICC: HeLa cells
Application & Usage WB: 1:1000-1:2000, ICC: 1:100-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist; a 34kDa form and a 29kDa form. Expression of the 29kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this MAb reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.


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