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Anti-Calnexin Antibody (CANX/1541)

Monoclonal Antibody to detect Calnexin in human samples
Catalog #: A1461
$395.00

Product Details

Cat # +Size A1461-100
Size 100 µg
Antibody Target CANX
Alternate Name Calnexin; CANX; CNX; IP90; Major histocompatibility complex class I antigen-binding protein p88; P90
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG2b, kappa
Immunogen Recombinant N-terminal fragment of human Calnexin protein
Accession # P27824
Gene ID 821
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC, WB
Positive Control IHC: human Renal Cell Carcinoma, human Small Intestinal Carcinoma
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, WB: 0.5-1ug/ml, IHC: 0.5-1 ug/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

It recognizes a protein of 90kDa, which is identified as Calnexin. Secretory and transmembrane proteins are synthesized on polysomes and translocate into the endoplasmic reticulum (ER) where they are often modified by the formation of disulfide bonds, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including calnexin. It is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.


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