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Anti-CALCA/CALCB, Humanized Antibody

Biosimilar to Eptinezumab, monoclonal antibody that targets CALCA/CALCB
Catalog #: A2217

Product Details

Cat # +Size A2217-100
Size 100 μg
Antibody Target CALCA/CALCB
Alternate Name ALD403, CT, KC, PCT, CGRP, CALC1, CGRP1, CGRP-I, CGRP-alpha, CALC2, CGRP2, CGRP-II
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CALCA/CALCB
Accession # DB14040
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar is a fully humanized monoclonal antibody that targets alpha and beta isoforms of calcitonin gene-related peptide (CALCA and CALCB). Calcitonin gene-related peptide (CGRP) is a neuropeptide that is released by the nerve endings of nociceptive (trigeminal) neurons. In addition to dilating meningeal vessels, CGRP causes extravasation of plasma protein and degranulation of mast cells. Degranulation of mast cells releases pro-inflammatory cytokines and causes neurogenic inflammation. Inflammation promotes sensitization of trigeminal neurons that carry the pain stimuli to the thalamus, hypothalamus, and cortex, thus resulting in migraine attacks.

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