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Anti-C5, Humanized Antibody

Biosimilar to Eculizumab, monoclonal antibody that targets C5
Catalog #: A2138
$415.00

Product Details

Cat # +Size A2138-100
Size 100 μg
Antibody Target Complement C5
Alternate Name C5D, C5a, C5b, ECLZB, CPAMD4, C5, Complement C5
Host Recombinant
Antibody Type Monoclonal
Isotype IgG2/4, kappa
Accession # DB01257
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant humanized IgG2/4 kappa monoclonal antibody that inhibits the cleavage of C5 into C5a and C5b by C5 convertases. Inhibition of C5 cleavage prevents the generation of the terminal complement complex C5b-9. Both C5a and C5b-9 have proinflammatory and prothrombic properties and play a significant role in complement-mediated diseases such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).


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