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Anti-C1S, Humanized Antibody

Biosimilar to Sutimlimab, monoclonal antibody that targets C1S
Catalog #: A2205
$455.00

Product Details

Cat # +Size A2205-100
Size 100 μg
Antibody Target C1S
Alternate Name EDSPD2, Complement C1s, Complement Component 1 Subcomponent S, C1 Esterase
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Accession # DB14996
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a humanized IgG4 monoclonal antibody that targets human complement factor C1s. C1s is a serine protease that is part of the C1 complex which contains a pattern recognition receptor (C1q) and a C1s activating serine protease (C1r). Activation of C1 complex results in the formation of C3 convertase which cleaves to form C3a and C3b. Chronic activation of the complement system results in extravascular hemolysis which is responsible for the pathophysiology of anemia in cold agglutinin disease (CAD).


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