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Anti-Beta-2 Microglobulin Antibody (B2M/961)

Monoclonal antibody to detect Beta-2 Microglobulin in human samples
Catalog #: A1440

In stock

$325.00

Product Details

Cat # +Size A1440-100
Size 100 µg
Antibody Target Beta-2 Microglobulin
Alternate Name B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG2b, kappa
Immunogen Full length recombinant human B2M protein
Accession # P61769
Gene ID 567
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: Human cervical carcinoma, Human melanoma, Human endometrial carcinoma, Human bladder carcinoma, Human colon carcinoma, Human renal carcinoma
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 0.5-1 ug/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Recognizes a protein of 12 kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.


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