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Anti-Bcl-2 Antibody (100/D5 + 124)

Monoclonal antibody to detect Bcl-2 in human samples
Catalog #: A1435

In stock

$325.00

Product Details

Cat # +Size A1435-100
Size 100 µg
Antibody Target BCL2
Alternate Name Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG’s
Immunogen A synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2
Accession # P10415
Gene ID 596
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC, WB
Positive Control IHC: human non-Hodgkin's Lymphoma, FC: Jurkat cells, WB: human skin lysate
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, WB: 0.5-1ug/ml, IHC: 0.5-1 ug/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.


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