Product Details
| Cat # +Size | A1434-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | BAX |
| Alternate Name | Apoptosis regulator BAX cytoplasmic isoform beta, Apoptosis regulator BAX membrane isoform alpha, Bax isoform psi, Bax protein cytoplasmic isoform delta, Bax protein cytoplasmic isoform gamma, Bax zeta, Bcl-2-like protein 4, BCL2 associated X protein, BCL2 associated X protein omega, BCL2 associated X protein transcript variant delta2, BCL2L4 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1 |
| Immunogen | Recombinant full-length human BAX protein |
| Accession # | Q07812 |
| Gene ID | 581 |
| Appearance | Colorless liquid |
| Formulation | In 10 mM PBS with 0.05% BSA & 0.05% azide |
| Purification | Protein A/G purification |
| Species Reactivity | Human |
| Application | FC, IF, IHC, WB |
| Positive Control | IHC: Hodgkin's lymphoma, human melanoma |
| Application & Usage | FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, WB: 0.5-1ug/ml, IHC: 0.5-1 ug/ml |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Recognizes a protein of 21kDa, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
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