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Anti-Aurora B Antibody (AURKB/1521)

Monoclonal antibody to detect Aurora B in human samples
Catalog #: A1433

In stock

$325.00

Product Details

Cat # +Size A1433-100
Size 100 µg
Antibody Target AURKB
Alternate Name AIK2, AIM-1, ARK-2, AurB, AURKB, Aurora-1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, IPL1, Protein phosphatase 1 regulatory subunit 48 (PPP1R48), Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B, STK1, STK12, STK5
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG2b
Immunogen Recombinant human Aurora B protein fragment (aa 89-251)
Accession # Q96GD4
Gene ID 9212
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, WB
Positive Control WB: Recombinant Protein, Human Liver Lysate
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, WB: 0.5-1 ug/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.


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