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New

Anti-ATRX / RAD54 Antibody (39f)

Monoclonal antibody to detect ATRX/RAD54 in human samples
Catalog #: A1432

In stock

$325.00

Product Details

Cat # +Size A1432-100
Size 100 µg
Antibody Target ATRX
Alternate Name Alpha thalassemia/mental retardation syndrome X linked homolog, ATP-dependent helicase ATRX, ATR2, ATRX, DNA-dependent ATPase and helicase, MRXHF1, RAD54; RAD54L, SFM1, SHS, Transcriptional regulator ATRX, X-linked helicase II, X-linked nuclear protein, XH2, XNP, Znf-HX
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1, kappa
Immunogen Recombinant human ATRX protein
Accession # P46100
Gene ID 546
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC, WB
Positive Control IHC: human pancreas
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, WB: 0.5-1ug/ml, IHC: 0.5-1 ug/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 α to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with α thalassemia or ATRX syndrome.


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