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Anti-ATGL Antibody (Clone# ARC1192)

Rabbit monoclonal antibody to detect the expression of ATGL in human, mouse, and rat samples
Catalog #: A2238
$345.00

Product Details

Cat # +Size A2238-100
Size 100 μl
Antibody Target ATGL
Alternate Name ATGL, TTS2, PEDF-R, FP17548, TTS-2.2, iPLA2zeta, 1110001C14Rik, PNPLA2, EC 3.1.1.3, Desnutrin, TTS2.2, IPLA2-Zeta
Host Rabbit
Antibody Type Monoclonal
Isotype IgG
Immunogen Synthetic peptide derived from human ATGL
Accession # Q96AD5
Gene ID 57104
Appearance Colorless liquid
Formulation In PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application Western Blotting
Application & Usage WB 1:500 - 1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Adipose Triglyceride Lipase (ATGL) is a 54 kDa lipase that belongs to patatin-like phospholipase domain containing (PNPLA) family. It is highly expressed in white and brown adipose tissue whereas a lower expression is detected in other tissues such as the liver, skeletal muscle, lung, and heart. One of the main functions of ATGL is to catalyze the initial step of lipolysis which involves the conversion of triacylglycerol (TAG) to diacylglycerol (DAG). In immune cells (such as macrophages, neutrophils), ATGL promotes pro-inflammatory response by contributing to the production of IL-6 and arachidonic acid, which are precursors of eicosanoids. In non-immune cells (such as heart, adipose tissue, liver, skeletal muscle), it inhibits the production of proinflammatory cytokines and chemokines. ATGL is downregulated in multiple human cancers such as the pancreas, liver, and lung. Mutations in the ATGL gene are associated with neutral lipid storage disease with myopathy.


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