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Product Details
| Cat # +Size | A1766-100 |
|---|---|
| Size | 100 μl |
| Antibody Target | APAF1-interacting protein |
| Alternate Name | Apaf1 Interacting Protein, APIP2, CG129, Monocyte/macrophage protein 19, MTNB, dJ179L10.2 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Accession # | Q96GX9 |
| Gene ID | 51074 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Purification | Affinity purification |
| Species Reactivity | Mouse, Human |
| Application | Immunohistochemistry (IHC), Western Blotting |
| Application & Usage | WB 1:200-1:1000, IHC 1:25-1:100 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury.The protein highly expressed in skeletal muscle and heart and binds to the CARD of Apaf-1 in competition with caspase-9. Exogenous APIP inhibits cytochrome c-induced activation of caspase-3 and caspase-9, and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria.
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