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Anti-ANPEP Antibody

Rabbit polyclonal antibody to detect the expression of ANPEP in human and mouse samples
Catalog #: A2100
$325.00

Product Details

Cat # +Size A2100-100
Size 100 μl
Antibody Target ANPEP
Alternate Name Alanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; AMPN_HUMAN; ANPEP; AP M; AP N; AP-M; AP-N; APN; CD 13; CD13; gp150; hAPN; LAP 1; LAP1; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; p150; PEPN
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant Human Aminopeptidase N protein
Gene ID 290
Appearance Colorless liquid
Formulation In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300
Purification Protein G purified
Species Reactivity Mouse, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Application & Usage WB 1:500-1:5000, IHC 1:20-1:200, IF 1:50-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.


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