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Anti-ANGPTL3 (Evinacumab), Human IgG4 Antibody

The biosimilar is a human monoclonal antibody that targets ANGPTL3 and reverses its inhibitory activity on LPL. This results in increased clearance of LDL-C from the blood
Catalog #: A2171

Product Details

Cat # +Size A2171-100
Size 100 μg
Antibody Target ANGPTL3
Alternate Name REGN 1500, REGN1500, ANL3, ANG-5, FHBL2, ANGPT5
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human ANGPTL3
Accession # DB15354
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar is an investigational human monoclonal antibody that targets angiopoietin-like 3 inhibitor (ANGPTL3). ANGPTL3 is primarily expressed in the liver and it inhibits LPL activity and endothelial lipase activity. This prevents the clearance of lipids and raises the concentration of triglycerides and LDL-C in the blood. The antibody binds with high affinity and specificity to ANGPTL3 and reverses the inhibitory action on LPL, thus promoting the clearance of LDL-C from the blood. The original drug was awarded breakthrough therapy designation by the FDA to treat patients suffering from homozygous familial hypercholesterolemia (HoFH).

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