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Anti-Angiopoietin-2 Antibody

Polyclonal antibody to detect endogenous levels of ANGPT2 in human, mouse and rat samples
Catalog #: A1291
$295.00

Product Details

Cat # +Size A1291-100
Size 100 µg
Antibody Target ANGPT2
Alternate Name Angiopoietin-2, ANG-2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Angiopoietin-2
Accession # O15123
Gene ID 285
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB
Positive Control WB: Hela, Raw264.7, H9C2 whole cell lysate
Application & Usage WB; 1:500 – 1:1000
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.


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