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Anti-AMACR / p504S Antibody (AMACR/1723)

Monoclonal antibody to detect AMACR in human samples
Catalog #: A1428

In stock

$325.00

Product Details

Cat # +Size A1428-100
Size 100 µg
Antibody Target AMACR
Alternate Name Alpha-methylacyl-CoA Racemase, CBAS4, Da1-8, Macr1, RACE, RM
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG
Immunogen Recombinant human full-length AMACR protein
Accession # Q9UHK6
Gene ID 23600
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application IF, IHC
Positive Control IHC: human prostate carcinoma
Application & Usage IF: 1-2 ug/ml, IHC: 1-2 ug/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This antibody recognizes a protein of 54kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and β-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.


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