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Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

Monoclonal antibody to detect alpha 5 beta 1 Integrin in human samples.
Catalog #: A1092
$625.00

Product Details

Cat # +Size A1092-200
Size 200 µg
Antibody Target ITGA5
Alternate Name Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG4, kappa
Immunogen Heterodimeric α5β1Fc fusion protein
Accession # P08648
Gene ID 3678
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification Affinity purified using protein A
Species Reactivity Human
Application ELISA; FC; IF; Block; IHC
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.


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