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Anti-Alkaline Phosphatase Antibody (ALPL/597)

Monoclonal antibody to detect Alkaline Phosphatase in human samples
Catalog #: A1426

Product Details

Cat # +Size A1426-100
Size 100 µg
Antibody Target Alkaline Phosphatase
Alternate Name Alkaline phosphatase, germ cell; Alkaline phosphatase, testicular and thymus, Alkaline phosphatase liver/bone/kidney, Alkaline phosphatase, tissue-nonspecific, ALPG, ALPL, Germ cell alkaline phosphatase, Testicular and thymus alkaline phosphatase, Tissue non-specific alkaline phosphatase, Tissue nonspecific ALP (TNAP or TNSALP)
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1, kappa
Immunogen Recombinant human ALPL protein
Accession # P05186
Gene ID 249
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: human endometrial carcinoma, human testicular carcinoma, human ovarian carcinoma, human colon carcinoma
Application & Usage FC: 0.5-1 ug/1X106 cells in 0.1 ml, IF: 0.5-1 ug/ml, IHC: 1:50-1:100
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

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