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Anti-11-Dehydro TXB2 Antibody

Recombinant mouse monoclonal antibody to detect 11-dehydro Thromboxane B2 expression in human urine samples
Catalog #: A2165
SKU-Size Size Price Qty
A2165-100 100 dtn
$59.00
A2165-500 500 dtn
$239.00
More Sizes Get Quote

Product Details

Antibody Target 11-Dehydro TXB2
Alternate Name 11-Dehydro-thromboxane B2, 11-Dehydro-txb2, 11-dehydrothromboxane B2, 11-Keto-thromboxane B2, 11dhTxB2 antibody
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1
Appearance Colorless liquid
Formulation In 500 mM Diethanolamine, 1.0 M NaCl, 10 mM EDTA, 1% BSA, pH 8.7
Purification Protein A purified
Application ELISA
Application & Usage The monoclonal antibody has been validated using human urine sample in 11-Dehydrothromboxane B2 ELISA Kit (BioVision Catalog# E4900-100)
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Thromboxane A2 (TxA2) is a prostaglandin metabolite that is metabolically derived from arachidonic acid (AA) via the action of cyclooxygenases (COX1 in platelets and COX2 in monocytes and endothelial cells). TxA2 is a vasoactive agent that regulates blood flow and blood pressure. Additionally, it acts as a pro-thrombotic agent that promotes the activation and aggregation of platelets. However, TxA2 is highly unstable with a short half-life (20-30 secs). It is readily converted to a stable metabolite thromboxane B2, which further undergoes dehydrogenation to form 11-dehydro thromboxane B2 (11dhTxB2). 11dhTxB2 is excreted in urine and has a longer half-life than TxA2. The metabolite is unaffected by the ex vivo platelet activation and other pre-analytical variables and hence is a valid biomarker to determine platelet activity. 11dhTxB2 is found to be elevated in multiple atherothrombotic diseases. Additionally, an elevated level of 11dhTxB2 in urine indicates aspirin resistance in patients receiving antiplatelet aspirin therapy.


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