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ANPEP/CD13 Antibody (Clone # 505CT12.1.2)

Monoclonal Antibody to detect ANPEP/CD13 in human samples.
Catalog #: 6794

In stock

$245.00

Product Details

Cat # +Size 6794-100
Size 100 μl
Antibody Target ANPEP/CD13
Alternate Name ANPEP; APN; CD13; PEPN; Aminopeptidase N; Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG2a
Immunogen This ANPEP/CD13 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from human ANPEP/CD13.
Accession # P15144
Gene ID 290
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Purification Protein G purification followed by dialysis against PBS
Species Reactivity Human.
Application Western blot.
Positive Control Western blot: HepG2 cell lysate.
Application & Usage WB: 1:100 – 1:250
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD13, or aminopeptidase N, is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin, including monocytes, basophils, eosinophils, neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells, fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor (bFGF) expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.


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