Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

ANGPTL-3, Human Recombinant

Inhibits lipoprotein lipase (LPL) and endothelial lipase (EL)
Catalog #: P1283

In stock

SKU-Size Size Price Qty
P1283-10 10 μg
$115.00
P1283-50 50 μg
$295.00
More Sizes Get Quote

Product Details

Alternate Name Angiopoietin-like protein 3, ANG-5, ANGPT5, Angiopoietin-5, Angiopoietin-related protein 3, ANGPTL3
Gene Symbol ANGPTL3
Accession # Q9Y5C1
Source CHO cells
Appearance Lyophilized
Physical Form Description Lyophilized from 10mM Sodium Phosphate, pH 7.5.
Molecular Weight 62 kDa
Purity by SDS-PAGE ≥ 98%
Endotoxin Level <0.1 EU/μg
Biological Activity Measured by its binding ability to recombinant αvβ3 integrin in a functional ELISA.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Amino Acid Sequence SRIDQDNSS FDSLSPEPK SRFAMLDDV KILANGLLQ LGHGLKDFV HKTKGQIND IFQKLNIFD QSFYDLSLQ TSEIKEEEK ELRRTTYKL QVKNEEVKN MSLELNSKL ESLLEEKIL LQQKVKYLE EQLTNLIQN QPETPEHPE VTSLKTFVE KQDNSIKDL LQTVEDQYK QLNQQHSQI KEIENQLRR TSIQEPTEI SLSSKPRAP RTTPFLQLN EIRNVKHDG IPAEC
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is primarily expressed in the liver and can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind alpha-5/beta-3 integrin’s leading to endothelial cell adhesion and migration. Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 62 kDa, and contains 452 amino acid residues including a C-terminal His tag.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.