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Angiostatin K1-3, human recombinant

A specific inhibitor of endothelial cell growth and angiogenesis
Catalog #: 4920
SKU-Size Size Price Qty
4920-20 20 μg
$105.00
4920-100 100 μg
$235.00
4920-1000 1 mg
$1,980.00
More Sizes Get Quote

Product Details

Alternate Name Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen
Accession # P00747
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from PBS
Molecular Weight 30.0 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Biological Activity The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10⁵ Units/mg.
Reconstitution Instructions Reconstitute in PBS to a concentration of 1.0 mg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.


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