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Androgen Receptor Antibody

Polyclonal Antibody to detect AR in human and mouse samples
Catalog #: 6710
$245.00

Product Details

Cat # +Size 6710-100
Size 100 μl
Antibody Target AR
Alternate Name AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
Accession # P10275
Gene ID ANDR
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Species Reactivity Human, Mouse
Application Western blot, IHC
Positive Control Western blot: HeLa and mouse brain lysate, IHC: human liver tissue
Application & Usage Western blot: ~1:1000, IHC: ~1:10-1:50
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding results in an at least 6-fold increase in androgen receptor stability.


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