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ANA-12

A potent and selective TrkB antagonist
Catalog #: 2878
SKU-Size Size Price Qty
2878-10 10 mg
$135.00
2878-50 50 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
Appearance White solid
CAS # 219766-25-3
Molecular Formula C₂₂H₂₁N₃O₃S
Molecular Weight 407.49
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O
InChi InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26)
InChi Key TUSCYCAIGRVBMD-UHFFFAOYSA-N
MDL Number MFCD00117444
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ANA-12 is a potent and selective TrkB antagonist that prevents activation of the receptor by BDNF with a high potency. It binds selectively to TrkB and inhibits processes downstream of TrkB without altering TrkA and TrkC functions. In adult mice model ANA-12 decreases TrkB activity in the brain without affecting neuronal survival. Displays antidepressant properties.


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