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AN-2728

A potent phosphodiesterase 4 (PDE4) inhibitor
Catalog #: B2220
SKU-Size Size Price Qty
B2220-5 5 mg
$75.00
B2220-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)oxy)benzonitrile; Crisaborole
Appearance Crystalline solid
CAS # 906673-24-3
Molecular Formula C₁₄H₁₀BNO₃
Molecular Weight 251.04
Purity ≥98% by HPLC
Solubility DMSO (~30 mg/ml)
SMILES B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O
InChi InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChi Key USZAGAREISWJDP-UHFFFAOYSA-N
PubChem CID 44591583
MDL Number MFCD17169940
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AN-2728 is a boron-based, topical anti-inflammatory agent that acts as a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC₅₀s = 6.12, 6.41, and 0.73 µM, respectively). AN-2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC₅₀ values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.


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