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A protein phosphatase methylesterase-1(PME-1) inhibitor
Catalog #: B2714
SKU-Size Size Price Qty
B2714-5 5 mg
B2714-25 25 mg
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Product Details

Alternate Name (E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136
Peptide Sequence N/A
Appearance Yellow solid
CAS # 1313613-09-0
Molecular Formula C₁₉H₁₃FN₃O₆S₂
Molecular Weight 461.44
Purity ≥98% HPLC
Solubility ~ 4 mg/ml DMSO
SMILES C1=CC(=CC(=C1)S(=O)(=O)N2C=CC=C2C=C(C#N)S(=O)(=O)C3=CC=C(C=C3)F)[N+](=O)[O-]
InChi InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+
PubChem CID 44607965
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.

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