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Amsacrine

A topoisomerase II inhibitor
Catalog #: B2445

In stock

SKU-Size Size Price Qty
B2445-10 10 mg
$75.00
B2445-50 50 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name Amsidine, N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide, m-AMSA
Appearance Crystalline solid
CAS # 51264-14-3
Molecular Formula C₂₁H₁₉N₃O₃S
Molecular Weight 393.46
Purity ≥98%
Solubility >8 mg/ml in DMSO
SMILES COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42
InChi InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23)
InChi Key XCPGHVQEEXUHNC-UHFFFAOYSA-N
PubChem CID 2179
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Amsacrine is a potent DNA intercalating and an antineoplastic agent. One of the ways amsacrine works is by blocking an enzyme topoisomerase 2. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols.


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