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AMPK⍺2 Antibody

Catalog #: 3117
$325.00

Product Details

Cat # +Size 3117-100
Size 100 µg
Antibody Target AMPK⍺2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide selected from the C-terminal region of human PRKAA2
Accession # P54646
Gene ID 5563
Appearance Colorless liquid
Concentration 0.25 mg/ml
Formulation 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Affinity purified
Species Reactivity Human, mouse
Application ELISA, Western blot, Immunohistochemistry
Application & Usage The antibody can be used for ELISA (0.25 µg/ml), Western blotting (2.5 – 5.0 µg/ml) and Immunohistochemistry (5 – 25 µg/ml).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart sμggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.


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