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AMPK⍺2 Antibody

Catalog #: 3169
$325.00

Product Details

Cat # +Size 3169-100
Size 100 µg
Antibody Target AMPK⍺2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH conjugated synthetic peptide between 476-507 amino acids from the C-terminal region of human AMPK alpha2.
Accession # P54646
Gene ID 5563
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg (1 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Ammonium sulphate precipitated
Species Reactivity Human, mouse
Application Western blot
Application & Usage The antibody can be used for and Western blotting (1:1000 dilution).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart sμggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.


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