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AMMC iodide

A useful substrate for human cytochrome P450 CYP2D6
Catalog #: 2873
SKU-Size Size Price Qty
2873-5 5 mg
$265.00
2873-25 25 mg
$975.00
More Sizes Get Quote

Product Details

Alternate Name 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin iodide
Appearance Off-white solid
Molecular Formula C₁₈H₂₆INO₃
Molecular Weight 431.31
Purity ≥98% by NMR
Solubility Acetonitrile
SMILES CC[N+](C)(CC)CCC1=C(C2=C(C=C(C=C2)OC)OC1=O)C.[I-]
InChi InChI=1S/C18H26NO3.HI/c1-6-19(4,7-2)11-10-16-13(3)15-9-8-14(21-5)12-17(15)22-18(16)20;/h8-9,12H,6-7,10-11H2,1-5H3;1H/q+1;/p-1
InChi Key OAQIUABCTPFMOC-UHFFFAOYSA-M
PubChem CID 15487105
MDL Number MFCD13184322
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AMMC iodide is a useful substrate for the human cytochrome P450 CYP2D6 isozyme. It is demethylated to the fluorescent product 3-[2-(N,N-diethyl-N-methyl ammonium)ethyl]-7-hydroxy-4-methylcoumarin (AMHC). After the AMMC is hydrolyzed, the pH is increased by addition of base for optimal fluorescence detection. AMMC has been used with human liver microsomes to determine CYP2D6 activity and inhibition.


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