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Amidepsine A, Humcola sp.

A diacylglycerol acyltransferase (DGAT) inhibitor
Catalog #: 2147
SKU-Size Size Price Qty
2147-500 500 µg
$215.00
2147-1000 1 mg
$415.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-[[4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoyl]oxy]-2-hydroxy-6-methylbenzoyl]-L-alanine
Appearance Off-white solid
CAS # 169181-28-6
Molecular Formula C₂₉H₂₉NO₁₁
Molecular Weight 567.55
Purity ≥95% by HPLC
Solubility DMSO or EtOH
SMILES CC1=CC(=CC(=C1C(=O)NC(C)C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O
InChi InChI=1S/C29H29NO11/c1-13-8-18(10-20(31)23(13)26(33)30-16(4)27(34)35)40-28(36)24-14(2)9-19(11-21(24)32)41-29(37)25-15(3)7-17(38-5)12-22(25)39-6/h7-12,16,31-32H,1-6H3,(H,30,33)(H,34,35)
InChi Key XQGKRCPZJSNFEL-UHFFFAOYSA-N
PubChem CID 10099481
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A diacylglycerol acyltransferase (DGAT) inhibitor. Shows inhibitory effect in rat liver microsomes (IC₅₀ = 10.2 µM) and Raji cells (IC₅₀ = 15.5 µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.


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