A protein methyltransferase inhibitor
Catalog #: 2300 | abID: ab144631

Product Details

abID ab144631
Alternate Name 2′,4′,5′,7′-Tetrabromofluorescein disodium salt, Acid Red 87, Bromo acid J. TS, XL, or XX, Bromofluorescein, Bronze Bromo ES, Eosin yellowish
Peptide Sequence No
Appearance Brown to dark red solid
CAS # 17372-87-1
Molecular Formula C₂₀H₆Br₄Na₂O₅
Molecular Weight 691.85
Purity ≥90% (based on the anhydrous material)
Solubility H2O (1 mg/ml)
SMILES C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]
InChi InChI=1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
PubChem CID 11048
MDL Number MCFD00005040
Handling Protect from air and light
Storage Conditions 4 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases (HKMTs) (DOT1 and SET7, but not Suv39H1 and Suv39H2).

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