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AMI-1

A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor
Catalog #: 1943
SKU-Size Size Price Qty
1943-5 5 mg
$110.00
1943-25 25 mg
$440.00
More Sizes Get Quote

Product Details

Alternate Name Arginine N-methyltransferase inhibitor-1
Appearance Brown solid
Molecular Formula C₂₁H₁₂N₂O₉S₂Na₄
Molecular Weight 592.42
Purity ≥98% by NMR
Solubility DMSO or Ethanol or water
SMILES C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])[O-].[Na+].[Na+].[Na+].[Na+]
InChi InChI=1S/C21H16N2O9S2.4Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;;;/q;4*+1/p-4
InChi Key OEJIOAHFKHHDAW-UHFFFAOYSA-J
PubChem CID 16760626
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor (IC₅₀ = 8.8 μM for human PRMT1 and 3.0 μM for yeast Hmt1p ). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Also acts as a HIV-1 RT polymerase inhibitor (IC₅₀ = 5.0 μM).


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