A potent c-Met inhibitor
Catalog #: B3397 | abID:

Product Details

Alternate Name N-[3,6-bis[[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl]-10-nitrosoanthracen-9-yl]hydroxylamine Tegatrabetan
Appearance Solid
CAS # 913376-83-7
Molecular Formula C₃₀H₂₉N₅O₅
Molecular Weight 539.58
Purity ≥98% by HPLC
Solubility >25 mg/ml DMSO
InChi InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
PubChem CID 24764449
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AMG-458 is a potent c-Met inhibitor (IC50 = 60 nM). Significantly inhibits tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight.

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