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A selective serotonin reuptake inhibitor
Catalog #: B3317
SKU-Size Size Price Qty
B3317-5 5 mg
B3317-25 25 mg
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Product Details

Alternate Name 6-[(1R)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one AMG337
Appearance Crystalline solid
CAS # 1173699-31-4
Molecular Formula C₂₃H₂₂FN₇O₃
Molecular Weight 463.5
Purity ≥98%
Solubility >30 mg/ml DMSO
InChi InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1
PubChem CID 44181686
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20 ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AMG-337 is a potent and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, that subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to block tumor growth in a c-Met-dependent xenograft model in mice (ED50 = 0.3 mg/kg).

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