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AMG-208

A c-Met inhibitor
Catalog #: 2553

In stock

SKU-Size Size Price Qty
2553-5 5 mg
$165.00
2553-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline
Appearance White to off-white solid
CAS # 1002304-34-8
Molecular Formula C₂₂H₁₇N₅O₂
Molecular Weight 383.4
Purity ≥98% by HPLC
Solubility DMSO (~ 1 mg in ml) or EtOH (~ 1 mg/ml)
SMILES COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5
InChi InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
InChi Key HEAIZQNMNCHNFD-UHFFFAOYSA-N
PubChem CID 24864821
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AMG-708 is a selective small-molecule inhibitor (IC₅₀ = 9.3 nM) of the proto-oncogene c-Met with potential antineoplastic activity. AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met.


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