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AMG-925

A potent and orally bioavailable dual FLT3/CDK4 inhibitor
Catalog #: B1959

In stock

SKU-Size Size Price Qty
B1959-5 5 mg
$125.00
B1959-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-hydroxy-1-[2-[[9-(4-methylcyclohexyl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]ethenone
Appearance Crystalline solid
CAS # 1401033-86-0
Molecular Formula C₂₆H₂₉N₇O₂
Molecular Weight 471.55
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5
InChi InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)
InChi Key BBUVDDPUURMFOX-UHFFFAOYSA-N
PubChem CID 60202647
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AMG-925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC₅₀ of 1 nM and 3 nM, respectively. It inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb(+)) and U937 (FLT3(WT)) and induces cell death in MOLM13 (FLT3(ITD)).


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