A selective RARα agonist and stem cell fate modulator
Catalog #: 2635 | abID:

Product Details

Alternate Name 4-​​[[(5,​​6,​​7,​​8-​​tetrahydro-​​5,​​5,​​8,​​8-​​tetramethyl-​​2-​​naphthalenyl)​carbonyl]​amino]​-​benzoic acid; RO 40-6055; CD336; NSC 608001
Appearance White solid
CAS # 102121-60-8
Molecular Formula C₂₂H₂₅NO₃
Molecular Weight 351.44
Purity >98%
Solubility DMSO (~ 15 mg/ml)
InChi nChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
PubChem CID 2126
MDL Number MFCD00673916
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.

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