A potent inhibitor of CDK1/cyclin B
Catalog #: 1897 | abID:

Product Details

Alternate Name 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Appearance Yellow to brown solid
CAS # 237430-03-4
Molecular Formula C₁₆H₁₁N₃O₃
Molecular Weight 293.28
Purity ≥95% by HPLC
Solubility DMSO
SMILES C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]
InChi InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
PubChem CID 5005498
MDL Number MFCD02683579
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ =35 nM). Also inhibits CDK2/cyclin A, CDK2/cyclin E (IC₅₀ = 200 nM), CDK5/p25 (IC₅₀ = 40 nM), CDK5/p35 (IC₅₀ = 40 nM) and GSK-3β.

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