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Alpha1 Antitrypsin Antibody

Polyclonal Antibody to detect Alpha1 Antitrypsin in Human, Mouse, Rat samples
Catalog #: 7009
SKU-Size Size Price Qty
7009-30T 30 µg
$89.00
7009-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Alpha1 Antitrypsin
Alternate Name Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Host Rabbit
Antibody Type Polyclonal
Isotype rabbit IgG
Immunogen Human alpha1 antitrypsin (Cat # 7294)
Accession # P01009
Gene ID 5265
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Purification Affinity purified rabbit IgG
Species Reactivity Human, Mouse, Rat
Application Western blot
Positive Control Western blot: h serum, m muscle, rat kidney, h alpha1 antitrypsin
Application & Usage Western blot: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.


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