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Alpha 2 Macroglobulin Antibody

Polyclonal Antibody to detect Alpha 2 Macroglobulin in Human, Mouse, Rat samples
Catalog #: 7015
SKU-Size Size Price Qty
7015-30T 30 µg
$89.00
7015-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Alpha 2 Macroglobulin
Alternate Name C3 and PZP-like alpha-2-macroglobulin domain containing protein 5, A2M, CPAMD5, FWP007
Host Rabbit
Antibody Type Polyclonal
Isotype rabbit IgG
Immunogen Human alpha 2 Macroglobulin (Cat # 7296)
Accession # P01023
Gene ID 2
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Purification Affinity purified rabbit IgG
Species Reactivity Human
Application Western blot
Positive Control Western blot: h serum, recombinant protein
Application & Usage Western blot: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Alpha 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. It functions as a broad-spectrum protease-binding protein. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells.


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