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Alpha 1 Antitrypsin, Human Plasma

An acute-phase plasma protein
Catalog #: 7294
$100.00

Product Details

Cat # +Size 7294-1000
Size 1 mg
Alternate Name Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Gene Symbol Serpin A1
Gene ID 5265
Accession # P01009
Source Human Plasma
Appearance Lyophilized
Physical Form Description Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
Molecular Weight 52 kDa
Purity by SDS-PAGE ≥95%
Biological Activity ≥ 5.0 IU/mg
Reconstitution Instructions In water or aqueous buffer
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.


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