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Alpha 1 Antichymotrypsin, Human Plasma

An acute-phase plasma protein
Catalog #: 7293

Product Details

Cat # +Size 7293-100
Size 100 μg
Alternate Name Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3, AACT, GIG24, GIG25
Gene Symbol SERPINA3
Gene ID 12
Accession # P01011
Source Human Plasma
Appearance Lyophilized
Physical Form Description Lyophilized from 20 mM Tris-HCl, pH 7.4, with 150 mM NaCl.
Molecular Weight 64 kDa
Purity by SDS-PAGE ≥95%
Biological Activity Shows 75-100% inhibition when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.
Reconstitution Instructions In water or aqueous buffer
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Alpha 1 antichymotrypsin is an acute-phase plasma protein found at 45 mg per 100 ml. ACT functions as a specific inhibitor of chymotrypsin-like serine proteases. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Clinically, it is elevated in inflammatory conditions, some malignancies, Crohn's disease, ulcerative colitis, and burn injuries. The PSA-ACT complex level is considered a biomarker for prostate cancer. Defects in this gene may be a cause of chronic obstructive pulmonary disease.

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