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Alpelisib

A potent and selective phosphatidylinositol-3 kinase α inhibitor
Catalog #: B1271
SKU-Size Size Price Qty
B1271-5 5 mg
$115.00
B1271-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; BYL719
Appearance White to off-white solid
CAS # 1217486-61-7 
Molecular Formula C₁₉H₂₂F₃N₅O₂S 
Molecular Weight 441.47
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
InChi InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
InChi Key STUWGJZDJHPWGZ-LBPRGKRZSA-N
PubChem CID 56649450
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Alpelisib (also known as BYL719), is a potent and selective phosphatidylinositol-3 kinase α inhibitor. It inhibits P110α, p110β, p110δ, and p110g with IC₅₀ values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibits the Akt phosphorylation with IC₅₀ values of 74 nM in Rat1-myr-p110α cells, 2.2 µM in Rat1-myr-p110β cells, and 1.2 µM in Rat1-myr-p110δ cells. 


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