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An irreversible ErbB2 and EGFR inhibitor
Catalog #: B3002
SKU-Size Size Price Qty
B3002-1 1 mg
B3002-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name AST-1306; N-(4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)acrylamide; N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide
Appearance Solid
CAS # 897383-62-9
Molecular Formula C₂₄H₁₈ClFN₄O₂
Molecular Weight 448.9
Purity >98%
Solubility ~20 mg/ml in DMSO
InChi InChI=1S/C24H18ClFN4O2/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15/h2-12,14H,1,13H2,(H,29,31)(H,27,28,30)
PubChem CID 24739943
MDL Number MFCD17169993
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Allitinib is a novel anilino-quinazoline compound that inhibits ErbB tyrosine kinases: epidermal growth factor receptor (EGFR) and ErbB2. It inhibits EGFR and ErbB2 with IC₅₀ values of 0.5 nM and 3 nM in cell-free assays. It inhibits the phosphorylation of EGFR and ErbB2 and downstream signaling in human cancer cells. It potently inhibits cell lines expressing high levels of ErbB2 such as Calu-3 lung adenocarcinoma and BT474 breast cancer cells with IC₅₀ values of 0.23 μM and 0.97 μM respectively. It inhibits tumor growth in the SK-OV-3 xenograft model.

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