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Alix, Human Recombinant

Cytoplasmic protein that interacts with apoptosis-associated proteins
Catalog #: P1576
SKU-Size Size Price Qty
P1576-20 20 μg
P1576-100 100 μg
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Product Details

Alternate Name Programmed cell death 6 interacting protein, AIP1, PDCD6IP, DRIP4, HP95
Gene Symbol PDCD6IP
Gene ID 10015
Accession # Q8WUM4
Source E. coli
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1 mM DTT
Molecular Weight 45.8 kDa (412aa) (N terminal His -Tag)
Purity by SDS-PAGE >95%
Amino Acid Sequence aa 1-392
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Alix, also known as PDCD6IP, is a cytoplasmic protein that interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. It's involved in concentration and sorting of cargo proteins of the multivesicular body for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. Overexpression of this protein and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Recombinant PDCD6IP protein was expressed in E. coli and purified by using conventional chromatography techniques.

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