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Aldose Reductase, human recombinant

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds
Catalog #: 7361
$240.00

Product Details

Cat # +Size 7361-100
Size 100 μg
Alternate Name Aldo-keto reductase family1, member B1, AKR1B1, ADR, ALDR1, ALR2, AR
Gene Symbol AKR1B1
Gene ID 231
Accession # P15121
Source E. coli
Appearance Liquid
Physical Form Description 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
Molecular Weight 35.8 kDa (316 aa, 1-316 aa), confirmed by MALDI-TOF.
Purity by SDS-PAGE ≥95%
Biological Activity Specific activity is approximately 0.2-0.9 units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH/min at 25°C. Specific activity was expressed in units/mg of protein.
Amino Acid Sequence MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DP
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily and catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Recombinant Aldose reductase (AKR1B) protein was expressed in E.coli and purified by using conventional chromatography techniques.


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