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Aldose Reductase Activity Kit (Colorimetric)

Aldose Reductase Activity Assay
Catalog #: K369

In stock

$455.00

Product Details

Cat # +Size K369-100
Size 100 assays
Kit Summary Aldose Reductase Activity Kit is a simple, sensitive assay to study Aldose Reductase activity in a variety of samples.
Detection Method Colorimetric assay at 340 nm
Species Reactivity All, Mammalian
Applications • Analysis of polyol pathway
• Measurement of Aldose Reductase activity in various tissues/cells
Features & Benefits • Can detect as little as 0.1 mU of Aldose Reductase activity in a variety of samples.
• Simple Procedure
• Sensitive Assay to measuring Aldose Reductase activity
Kit Components • Aldose Reductase
• DTT (1 M)
• AR Substrate
• UV transparent plate (96-well)
• NADPH
• AR Assay Buffer
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Aldose Reductase (Aldehyde Reductase; AR; ALR2; EC 1.1.1.21), a member of the aldo-keto reductase superfamily, catalyzes the NADPH-dependent reduction of a wide variety of aldoses (molecules containing carbonyl groups) to their corresponding alcohols. It is a key enzyme in the polyol (polyhydric alcohol) pathway and has been implicated to play a critical role in diabetes and cardiovascular complications. Aldose Reductase is the key factor in the reduction of glucose to sorbitol and its activity is higher during hyperglycemic conditions. The synthesis and accumulation of sorbitol due to AR activity is the main cause of diabetic complications, such as cataracts, retinopathy, neuropathy and nephropathy. Thus, AR could be used as a therapeutic target for the clinical treatment of secondary complications of diabetes. BioVision’s Aldose Reductase Activity Kit is based on the ability of AR to catalyze the oxidation of NADPH. The reaction progress is followed by monitoring the decrease in absorbance at 340 nm. The assay has been optimized to be monitored using a 96 well plate. The assay is simple, sensitive and can detect as little as 0.1 mU of Aldose Reductase activity in a variety of samples.


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