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Aldolase C (ALDOC) Antibody (CT)

Polyclonal Antibody to detect ALDOC in human, mouse, rat and monkey samples.
Catalog #: 6756
$245.00

Product Details

Cat # +Size 6756-100
Size 100 μl
Antibody Target ALDOC
Alternate Name ALDOC; ALDC; Fructose-bisphosphate aldolase C; Fructose-bisphosphate aldolase C; Brain-type aldolase
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This ALDOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-333 amino acids from the C-terminal region of human ALDOC.
Accession # P09972
Gene ID 230
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Species Reactivity Human. Predicted cross reactivity with mouse, rat and monkey samples.
Application Western blot, IHC.
Positive Control Western blot: human brain tissue lysate, IHC: human brain cerebellum.
Application & Usage Western blot: ~1:1000, IHC: ~1:10-1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fructose 1, 6-bisphosphate aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1, 6-bisphosphate. Fructose 1, 6-bisphosphate aldolase exists as three forms, the muscle-specific Aldolase A, the liver-specific aldolase B, and the brain-specific aldolase C. Aldolase A, B, and C arose from a common ancestral gene, from which aldolase B first diverged. Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagon and has been implicated in hereditary fructose intolerance disease. Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells. Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells.


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