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Aldolase C (ALDOC) Antibody (CT) Clone # 859CT9.5.3

Monoclonal Antibody to detect ALDOC in human and mouse samples.
Catalog #: 6755
$245.00

Product Details

Cat # +Size 6755-100
Size 100 μl
Antibody Target ALDOC
Alternate Name ALDOC; ALDC; Fructose-bisphosphate aldolase C; Fructose-bisphosphate aldolase C; Brain-type aldolase
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Purified His-tagged ALDOC protein was used to produce this monoclonal antibody.
Accession # P09972
Gene ID 230
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Species Reactivity Human and mouse.
Application Western blot.
Positive Control Western blot: HL-60,293 cell line and mouse brain, spleen lysates.
Application & Usage Western blot: ~1:1000.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fructose 1, 6-bisphosphate aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1, 6-bisphosphate. Fructose 1, 6-bisphosphate aldolase exists as three forms, the muscle-specific Aldolase A, the liver-specific aldolase B, and the brain-specific aldolase C. Aldolase A, B, and C arose from a common ancestral gene, from which aldolase B first diverged. Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagon and has been implicated in hereditary fructose intolerance disease. Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells. Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells.


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